Fancy running a campaign, event or project in your team but not sure what? We’ve put together a list of projects which staff have done over the past few years to give you some inspiration!
Extra Mile projects are all about doing something in your own department to raise awareness of, or tackle, a sustainability issue. It’s a great opportunity to engage the rest of your team, make a difference at City or in the local community and do something fun!
To find out more about how Extra Mile projects work, visit the Staff Hub here. Don’t forget, you can get in touch with the Sustainability Team for ideas, support and funding – simply email us at sustainable_city@city.ac.uk
Easy and simple to do projects
- Organise a sustainable bake off – it could be using ingredients which are Fairtrade, locally/home-grown, seasonal, organic or food cooked with as little energy as possible
- Switch to buying Fairtrade tea and coffee – you could organise a tasting event for the department
- Set up a waste collection in your department e.g. batteries, stamps, foreign coins, books
- Deliver a communications campaign to your team/students to raise awareness about a sustainability issue e.g. a series of tweets, blog post, poster campaign, quiz, crossword competition etc.
- Run a computer switch off campaign in your office
- Host a packaging-free lunch and encourage your team to bring in a lunch without any packaging
- Encourage your department to ditch the disposables – promote the 30p discount for drinks purchased with a reusable cup, request china from all hospitality orders, promote local bottle refill points, set up a plastic bag reuse point in the office, remind staff to say no to plastic straws and cutlery, raise the issue at a team meeting
- Switch to using non-bleached paper in the department
- Commit to ordering majority vegetarian food from hospitality – set up a process or agreement in the department
- Consolidate your deliveries
A little bit more challenging
- Organise a volunteer day for you and your team – staff have access to 2 days volunteering leave. Get in touch with the Volunteering Service or Organisational Development for more information and guidance about this.
- Host a Fairtrade event e.g. cheese and wine evening, coffee tasting, chocolate truffle making, Fairtrade-based games, film-screening. Fairtrade Fortnight takes place in the last week of February and the first week of March each year.
- Introduce Meatless Mondays into your office – you could hold a competition, keep a tally, share vegetarian recipes or recommended vegetarian food from favourite cafes/shops
- Host a film screening of an environmental film or documentary
- Organise a lunchtime talk for your team about a sustainable issue – you could invite an external speaker to speak
Ambitious
- Develop some induction materials for new starters to tell them about sustainability in your department
- Organise an event for staff/students during Sustainable City Week e.g. a swap shop. It usually takes place at the end of October or the beginning of November each year.
- Develop a sustainability map of the area – it could include things like clean commuter routes, where to shop or eat sustainably, or local parks/wildlife hotspots
- Go paper-free in your department and encourage lecturers to produce/share materials online rather than via hard copies
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Substitution of the 17α-H with an ethynyl group on nandrolone, a 19-nor anabolic
steroid with some progestational activity, will lead to a potent orally lively progestogen, this being referred to as norethisterone
(norethindrone), a steroid that’s nonetheless utilized in some contraceptives today.
Nonetheless, substitution with an ethyl group on nandrolone rather than ethynyl group ends in another anabolic steroid
known as norethandrolone, which also has oral exercise. Gestrinone,
is a pharmaceutically available progestogen that lacks the C-19 angular methyl group however has a 17α-ethynyl group, and it follows that reduction of this ethynyl
group to the tetrahydro product ought to make THG
a ‘potent’ androgen. This is indeed the case, as subsequently THG was discovered
to be a extremely potent androgen (and progestogen) in an in vitro bioassay system expressing human steroid
receptors (Death et al., 2004), and it promotes muscle accretion in orchidectomized male
rats (Jasuja et al., 2005). With structural
modifications to testosterone, the anabolic results of androgens can be enhanced but, even so,
these cannot be divorced completely from their androgenic effects.
Finally, solely 5 of the included titles utilized any kind of exercise intervention (14, sixteen, 20, 27, 32).
Though selective oestrogen receptor modulators (SERMs),
similar to tamoxifen and clomiphene, have a possible advantage over testosterone substitution, some caveats
need to be considered. SERMs act as an oestrogen or an anti-oestrogen, relying
on the uncovered tissue.
Whereas AAS usually are not explicitly recognised in the Diagnostic and statistical guide of mental issues (DSM 5) as certainly
one of 9 courses of medication [45], they may be thought of beneath the tenth ‘other (or
unknown) substance’ class. The DSM 5 determines the severity
of a substance use dysfunction from mild to extreme in accordance with the presence of up to 11 standards.
Criteria corresponding to tolerance, withdrawal, use of the substance in larger quantities, unsuccessful makes an attempt to cut back or cease utilizing the substance,
and time spent on activity associated to the substance use have all been identified as options of AAS dependence [44, 46].
A variety of hypotheses to elucidate AAS dependence have been put ahead [47, 48]
and suggestions for treating what has been described as steroid ‘abuse’ or dependence have lengthy been proposed
[49,50,51].
Certainly, folks taking AAS seldom disclose their use to clinicians, and it usually
only involves attention after the development of great antagonistic effects.
In current years, research has provided a more nuanced understanding of AAS use in relation to the varied characteristics and
motivations of customers [20–27], together with information of
the variability and patterns of drug use from both educational research [28–34] and other sources [35].
Present AAS abusers had the smallest testicular
volume (12.2 (0.7) ml) and former AAS abusers had a quantity of 17.four (0.8)
ml which was 4.eight (2.9; 6.8) ml smaller than that
of the control individuals who had largest testicular volume (Table 2).
Plasma total and free testosterone levels had been significantly decrease
amongst former AAS abusers than among control individuals and current AAS abusers,
the latter of whom exhibited considerably elevated plasma testosterone ranges, as anticipated.
The Two.5th– 97.5th percentiles for complete testosterone ranged from 12.4–32.three nmol/l among the
management participants and 5.7–31.four nmol/l among former AAS abusers.
Androgens are contraindicated in hypersensitivity to the drug, male breast and prostate most cancers, and severe cardiac, hepatic, or renal illness.
Moreover, testosterone have to be used cautiously in prepubescent clients due to
the risk of early bone maturation and early closure of
the epiphyseal growth plates.
Whereas it stays to be decided if and to what extent an AAS-induced increment in blood stress increases CVD
threat, it appears prudent to discourage use when an AAS user meets the standards for hypertension. If a patient continues utilizing AAS long-term nonetheless, therapy appears smart.
Long-standing untreated hypertension may exacerbate the detrimental results of AAS on cardiac construction and performance,
perhaps making blood strain therapy in this inhabitants notably
relevant.
Percentage of members of the HAARLEM study that used one of many under
talked about androgens during one cycle of anabolic steroids (based on label information).
Some characteristic clinical manifestations are nausea, pruritus, fatigue, jaundice, and darkish
urine with elevated bilirubin and ALP, but with out vital elevations of AST, ALT, and GGT.
Such traits are indicative of cholestasis with minimal irritation of
the liver or bile duct. Resolution normally occurs upon discontinuation of anabolic steroids, although some case
reports point out benefits of hydrocortisone and ursodeoxycholic acid treatment[13,39-42].
She combines a robust scientific background with compassion and is enthusiastic about empowering
people to manage their mental health. Some of probably the
most worrying consequences of steroid use are the results it has on conduct
and psychological health. The drugs may be taken by mouth, injected into a muscle,
or utilized to skin as a gel or in a patch. Anabolic steroids
may be administered via oral drugs, injections, topical lotions or gels, or
pores and skin patches.
Gonadally intact males will typically spend significantly extra time with the sexually receptive feminine (Feinberg et al., 1997).
Adolescent males receiving AAS remedy persistently showed a significantly greater choice for the sexually
receptive feminine compared to control males (Feinberg et
al., 1997; Keleta et al., 2007; Wesson and McGinnis, 2006).
However by 13 weeks after withdrawal, companion choice returned to inside
normal ranges (Feinberg et al., 1997). To our knowledge, associate desire has not been examined in AAS-treated adult males.
In hamsters, AAS considerably elevated both intromissions and
ejaculations in adolescent males (Salas-Ramirez et al.,
2008). In pubertal rats, AAS publicity elevated sexual behavior in some studies however had no effect
in others (Farrell and McGinnis, 2003; Keleta et al.,
2007; Wesson and McGinnis, 2006). A nearer inspection suggests that
this will likely to be because of prior sexual expertise.
Current data derives largely from the experiences of a small variety of physicians who’ve worked with sufferers undergoing
steroid withdrawal. They have realized that, in general, supportive therapy mixed with education about attainable withdrawal symptoms is sufficient in some instances.
AASs journey through the bloodstream to the muscle tissue, the place
they bind to an androgen receptor.
The strength of a steroid can vary considerably depending on the gender of the
consumer, females are way more sensitive to the consequences of anabolic steroids than males are.
Take Winstrol, for example; it’s thought of a potent steroid for female users,
yet it’s typically thought to be mild when utilized by males.
This gender-based variation in effectiveness can also be true in phrases of the dosage used.
The anabolic androgenic effects are linked to the androgen receptor (AR)-signaling motion. Androgen receptors are expressed in myosatellite cells (also named satellite cells); these are the precursors of skeletal muscle cells (Sinha-Hikim et al., 2004).
First, there was a scarcity of standardized
Anavar dosing for athletes for the
main AAS compounds studied.
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